- Alyssa is a feminine given name with multiple origins.
- Alyssa Jayne Milano (born December 19, 1972) is an American actress, producer, activist, and singer. She is known for her roles as Samantha Micelli in Who's the Boss?, Jennifer Mancini in Mel
- Alyssa Caymo Valdéz (born June 29, 1993) is a Filipino volleyball player who currently plays for a local club team named Creamline Cool Smashers.
- Alyssa Healy (born 24 March 1990), is an Australian cricketer who plays for the Australian women's national team and New South Wales in domestic cricket.
- Alyssa Michele Naeher (born April 20, 1988) is an American soccer goalkeeper for the Chicago Red Stars of the National Women's Soccer League (NWSL), the highest division of women's profession
- Justin Dwayne Lee Johnson, known by his stage name Alyssa Edwards (born January 16, 1980), is an American drag performer, choreographer, and businessperson.
- Alyssa Ashley Reid (born March 15, 1993) is a Canadian singer-songwriter. She rose to fame in 2011, following the release of her single "Alone Again".
- Alyssa Elaine Diaz (born September 7, 1985) is an American actress. She is known for her roles on television, such as Celia Ortega on the CBS daytime soap opera As the World Turns, Jasmine on
- Alyssa Mende Mastromonaco (born February 22, 1976) is a Senior Advisor and spokesperson for NARAL as of July 2018. She was previously the President of Global Communications Strategy & Talent
- Alyssa Elaine Miller (born July 4, 1989) is an American model. She has done print and runway work for numerous leading companies.
Pictured back row left to right: coach Laura Ewert, Jaymie Capron, Charli Johnston, Jazz Taylor, Ellen Fallis, Taylor Fiedler, Veronica Fuller-Evans, coach Gillian Sanders; front row: coach Sean Whalen, Jayden Mahoney, Cheyenne Mawby, McKayla Carr-Weeks, Leah Ewert, Sophie Skeath, Alyssa Black